Visualizando emociones, entrevista con Oliver Sacks


On July 6, 2009, Oliver Sacks answered selected viewer questions about how the brain responds to music, the therapeutic effects of music on various neurological disorders, and more.
Q: I have a six-year-old son with autism who loves to listen to Mozart. For him, it has a calming effect, and he just loves it. Over time, should we try to vary the types of classical music that he listens to (i.e., different compositions or different composers)? Or, in your experience, will persons continue to accrue the same mental/emotional benefits from the same pieces of music over long periods of time?

A: Musical taste is highly individual—some people may be calmed by Mozart, others find that Chopin works best. Still others might prefer the Beatles. Familiarity is comforting, and I know that there are certain pieces of music (Bach's Preludes and Fugues, for example) which I can listen to almost daily and never tire of—each time I hear something new. If your son prefers Mozart, by all means stick with it—but you might try to introduce other sorts of music as well.

Q: Do you think we are prewired for our music preferences? I find that folk and Celtic music speak to my soul. My son, who is a music major, is a jazz lover. We each hate each other's preferences. I don't understand why we are so different. My daughter, who is an autistic savant with vocal music, is totally eclectic in her musical tastes. She is able to memorize songs immediately.


A: I suspect that relatively little of our musical preference is prewired. It is more likely that they are formed by the music we are exposed to in our childhood and youth—but also colored by associations, experiences, and emotions which we link to a particular type of music.

Q: Can exposure to music at an early age (3-4 years old) influence or impact a child's current and future language and math ability or skills?

A: In the early 1990s, researchers at the University of California at Irvine designed a series of studies to see whether listening to music could modify nonmusical cognitive powers. They published several careful articles, in which they reported that listening to Mozart (compared to listening to "relaxation" music or silence) did temporarily enhance abstract spatial reasoning. The Mozart effect, as this was dubbed, not only aroused scientific controversy but excited intense journalistic attention and, perhaps unavoidably, exaggerated claims beyond anything intimated in the researchers' original modest reports.

The validity of such a Mozart effect has been disputed, but what is beyond dispute is the effect of intensive early musical training on the young, plastic brain. Takako Fujioka and her colleagues, for instance, examining auditory evoked potentials in the brain, have recorded striking changes in the left hemisphere of children who have had only a single year of violin training, compared to children with no training.

The implication of all this for early education is clear. Although a teaspoon of Mozart may not make a child a better mathematician, there is little doubt that regular exposure to music, and especially active participation in music, may stimulate development of many different areas of the brain—areas which have to work together to listen to or perform music. For the vast majority of students, music can be every bit as important educationally as reading or writing.

Q: I have a keen sense of time, but not pitch. A minor second sometimes sounds the same to me as a major seventh. Yet I wouldn't mistake a 16th-note triplet for a 32nd note. So I wonder: What is known about similarities or differences in the neural mechanisms for pitch distinguishing and time (rhythm) distinguishing?

A: Pitch and rhythm are processed in different parts of the brain, and their development does not necessarily go together, so one can have an acute tonal sense and a relatively poor rhythmic sense—or vice versa. But usually this is a relative matter. True tone-deafness is rather uncommon (perhaps five percent of the population), though I describe one lady in Musicophilia who cannot distinguish pitches at all—she says that music, to her, sounds like pots and pans clattering on the kitchen floor. Absolute "rhythm deafness" is rarer still—the neural systems which underlie rhythm seem to be more robust and perhaps more widespread in the brain.

Q: Why is it that it is possible to learn to play a tune in only one direction and not instantly be able to play it backwards? Things seem to run in sequence when they are remembered and only in one direction. Are there people who can sequence tonal memory rapidly in either direction?


A: Because the logic of the music, its narrative and trajectory, only make sense in one direction—unless the piece is deliberately designed as a musical palindrome. Nonetheless, I suspect that some musicians, and perhaps some musical savants, could reproduce a tune rapidly in either direction.

Q: What is the difference in brain activity between music you like and music you don't like?


A: Music which produces extreme pleasure, or "chills," activates the reward systems in the brain. But "appreciating" music or finding it "beautiful" are aesthetic value judgements of a more complex sort—and we do not, as yet, have a real science of neuroaesthetics, an idea of what specific brain activity goes with aesthetic sensibility and response.

Q: My sister is 80 years old and recently diagnosed with early Alzheimer's. Is there any data on the effects of music on these people? She is home alone all day and has very little stimulation.

Q: My grandfather "Zayde" has something called frontotemporal dementia, and his speaking is now difficult to understand and is getting noticeably worse. He doesn't seem to care about anything anymore, his behavior is bland, and he falls asleep in the middle of talking to people. I watched your show tonight, and I saw how you discovered that music helped all these people's brains. Can music help my Zayde's brain too?

A: Yes, people with frontotemporal dementia, like those with Alzheimer's or other dementias, will often respond to music, even when they are able to respond to little else. Music, especially familiar music which has personal emotional resonances, can help to orient and organize people with all kinds of dementia. Some people with frontotemporal dementia actually become rather hyper-musical, whistling or singing through much of the day.


Q: I'm doing a paper on the importance of music in everyday life. And I was wondering: Why is music such an effective tool for therapy?


A: Music works because everyone responds to it—and in many ways. The rhythm, the beat, is crucial in synchronizing and energizing movement—whether for athletes or people with movement disorders like Parkinson's disease or Tourette's syndrome. And old songs may be recognized and responded to even if there is dementia or deep amnesia—and such music can evoke feelings and memories that are otherwise lost.



Q: Has there been any study showing that music therapy can be helpful in curing or treating epilepsy?


A: I quote an example or two in Musicophilia, including one of a patient who has incessant seizures, which only stop when he plays music. So music can have efficacy for people with epilepsy, but for some people, music of a particular sort can actually trigger seizures. So this is a very individual thing.

PROYECTO "BLUE BRAIN" o la Ingeniería Inversa del Cerebro

El proyecto Blue Brain, consiste en un ambicioso estudio basado en la denominada ingeniería inversa del cerebro. En la Universidad suiza de Lausanne, se encuentra el inmenso ordenador formado por 2.000 microprocesadores que conforman el núcleo de procesamiento computacional que puede manejar 22,8 billones de operaciones por segundo. La intención es hacer funcionar a cada uno de estos microchips como una neurona real. La pretensión última es poder llegar a establecer el primer modelo del funcionamiento cerebral de "abajo hacia arriba" (bottom-up) basándose en una réplica exacta del sustrato neural a nivel molecular.
El proyecto se inicio en el año 2005 y no estuvo exento de críticas iniciales por sus ambiciosas intenciones, para muchos una mera quimera o un sueño imposible de materializar, pero para sus defensores el lema básico es que "para tratar de averiguar cómo funciona algo, lo mejor es reconstruirlo desde el principio".

La primera fase del proyecto (fase de viabilidad), parece estar llegando a su fin. En el plazo de unos dos años la supercomputadora "Cerebro Azul" pudo simular con exactitud una columna neocortical  del cerebro (que contiene aproximadamente 10.000 neuronas y cerca de 30 millones de conexiones sinápticas).

Para el lector interesado en ampliar la información o conocer los pormenores de este Proyecto Neurocientífico, le recomiendo visitar la siguiente web (en ingleś):   

Blue Brain Proyect (Escuela Politécnica Federal de Lausanne)


El proyecto Blue Brain representa, en definitiva, el primer intento a escala internacional de realizar una ingeniería inversa del cerebro de los mamíferos, a través de una labor coordinada de distintos laboratorios y un enfoque multidisciplinar. En mayo del pasado año, la participación española en este Proyecto se materializa en la denominada Cajal Blue Brain coordinada por la Universidad Politécnica de Madrid (Facultad de Informática/CesVima) y con la colaboración del Instituto Cajal del CSIC. Así, según declaraciones de Javier de Felipe, neurobiólogo de este Instituto y co-director del proyecto Cajal Blue Brain:

"La intención es que se produzcan avances significativos en el conocimiento del funcionamiento normal y disfuncional del cerebro, que sin duda servirán para explorar soluciones a problemas de salud mental y a enfermedades neurológicas intratables actualmente, como la enfermedad de Alzheimer"

En el siguiente vídeo, el propio Javier de Felipe explica algunos aspectos de este interesante proyecto de simulación computacional del cerebro:


Monitorizando el cerebro.

Vía Channel N.




El video muestra la historia real de Evan Moss y su lucha contra la epilepsia y la esclerosis tuberosa.

Eric Kandel: Biología molecular de la memoria y bases biológicas de la individualidad



“The Molecular Biology of Memory Storage and the Biological Basis of Individuality”
Center on the Developing Child at Harvard University

Distinguished Scholars Lecture Series
Eric R. Kandel, M.D.
Winner of the Nobel Prize in Physiology or Medicine, 2000

Tratamiento farmacológico del insomnio en pacientes psiquiátricos infantiles y adolescentes

Los trastornos del sueño son frecuentes en niños y adolescents con trastornos psiquiátricos, no obstante existen pocos fármacos disponibles para tratarlos. Solamente ciertos antihistamínicos H1 tienen autorización para ser comercializados para el tratamiento del insomnio infantil. Se han realizado muy poco estudios en niños sobre hipnóticos que son ampliamente utilizados en pacientes adultos: zoplicona, zolpidem y las benzodiacepinas hipnóticas. Sin embargo la melatonina se ha vuelto recientemente el hipnótico más estudiado en niños desde la comercialización de una forma de liberación sostenida que le dio el estatus de fármaco y mejoró sus propiedades farmacocinéticas. En psiquiatría infantil el tratamiento farmacológico del insomnio debería ser considerado en pacientes con trastorno por deficit de atención e hiperactividad, en los trastornos de espectro autista y en ansiedad/depresión. cuyos trastornos del sueño pueden ser agravados por el tratamiento con psicoestimulantes. © 2010 Société Française de Pharmacologie et de Thérapeutique.

Chevreuil C, Polard E, Gicquel G, Frémaux T, Bentué-Ferrer D.
Service de Psychiatrie Infanto-Juvénile, CH Guillaume Régnier, Rennes, France.

Resumen en PUBMED:
Therapie. 2010 1-2;65(1):1-12. Epub 2010 Mar 8.
PMID: 20205989 [PubMed - as supplied by publisher]